Chow, an associate professor in the Department of Human Genetics, University of Utah, will discuss "Flying to the Clinic: Drug Repurposing Screen for Rare Diseases" at 4:10 p.m. in 122 Briggs Hall and also via Zoom.
The Zoom link:
https://ucdavis.zoom.us/j/9 5882849672
"Dr. Chow's research has made a tremendous impact on the lives of patients with rare diseases as well as their families and caretakers," said molecular geneticist and physicist Joanna Chiu, professor and chair of the Department of Entomology and Nematology. "His research program provides a shining example of how one can leverage many of the advantages of the Drosophila fly model to investigate molecular mechanisms disrupted in human diseases and efficiently translate that to medical interventions andFDA-approved drugs." The Chiu lab is hosting the seminar.
Professor Chow says in his abstract: "Our lab is focused on understanding the role of genetic variation on disease outcomes. We employ quantitative and functional tools, in a variety of model organisms, to study how genetic variation impacts basic cellular traits important to human health. Our work in model organisms will help to model and inform studies of genetic variation in the human population. We hope to identify variation that can lead to more precise, personalized therapies, especially for rare disease."
He and his research team "leverage the powerful genetic tools available in the fruit fly (Drosophila melanogaster) to build and study models of rare diseases," according to research news published on the University of Utah website. "The Chow lab has developed a fly model of NGLY1 deficiency, providing many new insights into the biology underlying this devastating autosomal recessive, genetic disorder."
"Using the fly model, the Chow lab discovered NGLY1 deficiency results in the absence of a sugar known as GlcNAc, which is important for different cellular processes," Martha Davis wrote in the news story. "When provided with a dietary GlcNAC supplement, flies with NGLY1 deficiency are healthier and live longer, suggesting this supplement may help NGLY1 patients...The Chow lab hopes to continue to translate basic science research of rare diseases to the clinic. The generosity of donors like the Might Family make this type of work possible. The Might family supports this research in hope that someday a treatment, or even a cure, will be found for NGLY1 deficiency."
Chow expanded on his fruit fly research on a University of Utah website heralding Academia in Action: Treating Patients as Individuals. "Because the fruit fly is small, cheap and fast, we can do massive experiments that people in mouse labs can only dream of. We take a model of a particular rare disease, and we cross it into a couple hundred different genetic backgrounds in the flies. What that gives us is basically a number of fly strains that you can think of as different individuals with different genetic backgrounds, all with the same disorder.”
D. melanogaster is widely used for biological research in genetics, physiology, microbial pathogenesis, and life history evolution. "As of 2017, six Nobel Prizes have been awarded to drosophilists for their work using the insect," according to Wikipedia.
Chow received his bachelor's degree in biology, neurobiology and behavior from Cornell University in 2003. He completed his Ph.D. in human genetics in 2008 in the Department of Human Genetics at the University of Michigan, where he worked with Miriam Meisler. He completed his postdoctoral training as a co-mentored postdoc with Andy Clark and Mariana Wolfner at Cornell University.
For any technical Zoom issues, contact seminar coordinator Brian Johnson at brnjohnson@ucdavis.edu. The full list of spring seminars is here.
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